In recent years, the significant increase in healthcare costs has been driven by several factors, mainly the aging of the global population. The concept of Open Health is at the heart of this transformation, promoting transparency, collaboration and accessibility of health data. Open Health aims to create a secure and efficient ecosystem for sharing information between patients, healthcare professionals, researchers and developers. Interoperability is fundamental to Open Health, enabling different systems and devices to communicate and work together, improving the quality of care and promoting operational efficiency by eliminating redundancies and optimizing processes. This book explores the synergy between Open Health, interoperability and VBHC, showing how openness and data sharing can improve the quality of care, empower patients, accelerate technological innovation and contribute to the economic sustainability of healthcare systems.